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Which model folds what, what the alignment is worth, how to read pLDDT, PAE and ipTM, and when to compare predictors. On the transferrin receptor and a textbook complex.

An example VHH campaign against transferrin receptor 1. The target and the epitope are real; the pilot, the batch and the lab results are illustrative. Choose the site, pilot the generators, run the batch, score, review, and read what the lab says.

Score every residue of a structure, choose what to redesign and what to keep, design new sequences with four models, fold them back and read what came out. On a VHH bound to transferrin receptor 1.