Dyno Phi

Learn/Design a binder

  1. Target
  2. Epitope
  3. Pilot
  4. Generate
  5. Score
  6. Review
  7. Lab

Choose a target and a molecule

636residues in chain A of 9GH7, numbered 122 to 757

Human transferrin receptor 1, ectodomain

PDB 9GH7 · chain A · no gaps

Loading structure

    No sequence loaded.

    Molecule

    Dyno recommends

    • Germinalhunt · runs until enough designs pass

      Germinal is the experimentally validated VHH path and needs only a target and an epitope.

    • PXDesignbatch · a fixed number of designs

      Generate all-atom binder backbones with ByteDance PXDesign-d.

    See 3 more

    • BoltzGenbatch · a fixed number of designs

      BoltzGen diffuses, inverse-folds, refolds and ranks in one job, so a batch of candidates comes back already filtered.

    • RFantibodybatch · a fixed number of designs

      RFantibody diffuses CDR loops onto a supplied framework against the epitope.

    • RFD4-Proteinabatch · a fixed number of designs

      Co-design structure and sequence with RFD4-Proteina: protein binders, antibody/VHH CDRs, motif scaffolds, partial-diffusion refinement and inverse folding in one model.

    BoltzGen designs VHHs through its nanobody scaffold protocol with a design spec; RFD4-Proteina designs the CDRs onto the framework you supply.

    Do this in Phi

    Type the target into the composer: "Design VHH binders to TFR1, PDB 9GH7 chain A." Phi loads the structure and shows this chain summary.

    Next: EpitopeRead the docs →