Learn/Design a binder
Choose where to bind
8hotspot residues chosen, author numbered
Choose hotspots on the structure or the sequence
Loading structure
- hotspot
- target
No sequence loaded.
A150, A154, A156, A159, A160, A161, A193, A219
Configuring epitope selection in each model
| Model | Parameter | Value for this set |
|---|---|---|
| BoltzGen | params.hotspots | ["A150","A154","A156","A159","A160","A161","A193","A219"] |
| Germinal | params.hotspots | ["A150","A154","A156","A159","A160","A161","A193","A219"] |
| RFantibody | params.hotspots | ["A150","A154","A156","A159","A160","A161","A193","A219"] |
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| BindCraft | params.hotspots | ["A150","A154","A156","A159","A160","A161","A193","A219"] |
| Dyno Psi | params.hotspots | `hotspots` are required. `binder_center_of_mass` is required for the default `binder_centering=predefined`; set `binder_centering=sphere_exclusion` to omit it. The centre is then computed from the hotspots. Hotspots use 'Chain:Residue' form, e.g. 'A7:58'. |
| RFD4-Proteina | params.hotspots | ["A150","A154","A156","A159","A160","A161","A193","A219"] |
| RFdiffusion | params.hotspots | ["A150","A154","A156","A159","A160","A161","A193","A219"] |
| RFdiffusion 3 | params.hotspots | ["A150","A154","A156","A159","A160","A161","A193","A219"] |
| PXDesign | inputs.target_chains, 1-based | [29,33,35,38,39,40,72,98] (chain A starts at 122, so subtract 121) |
Do this in Phi
Open the target in the viewer and tap or click residues on the surface, or type the set. Phi keeps author numbering and converts for the model you pick.