Learn/Design a binder

Pilot before the batch

40%of scored designs pass on the best cell, Dyno Psi on the apical set, at these thresholds

Pass rate by generator and site · 50 designs planned per cell

Dyno Psiapical set18 of 45 scoredbatch
Dyno Psiapical domain4 of 41 scoredbatch
RFantibodyapical set6 of 42 scoredbatch
RFantibodyapical domain0 of 38 scoredbatch
Germinalapical set11 of 38 scoredhunt
Germinalapical domain1 of 40 scoredhunt

Thresholds

pLDDT ≥80pTM ≥0.55ipTM ≥0.5ipSAE ≥0.35iPAE ≤10.85 ÅBinder RMSD ≤3.5 ÅBinder pLDDT ≥Ranking score ≥gPDE ≤Confidence ≥iPAE ≤ ÅscRMSD ≤ ÅHotspot obedience ≥Clashes ≤Sequence adherence ≥Motif RMSD ≤ ÅCDR contacts ≥Cα RMSD to input ≤ ÅHelix ≥Sheet ≥

Do this in Phi

In a campaign, choose Pilot: 50 designs per generator per hotspot set, scored with your thresholds. The report shows pass rate per cell and nominates one for the batch.

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